Novel tyrosinase inhibitors from liquid culture of Neolentinus lepideus
نویسندگان
چکیده
منابع مشابه
Novel Sesquiterpene Ethers from Liquid Cultures of the Wood-Rotting Fungus Lentinus lepideus
Universität Hamburg, Institut für Organische Chemie, Martin-Luther-King-Platz 6, D-2000 Hamburg 13, Bundesrepublik Deutschland Z. Naturforsch. 43c, 24-28 (1988); received August 18/October 30, 1987 Dedicated to Professor Ewald Sprecher on the occasion of his 65th birthday Lentinus lepideus, Lentideusether, Terrestrol, Fungal Sesquiterpenes, Fungal Fragrance Compounds The brown-rot fungus Lentin...
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Anisaldehyde characterized in the seeds of Pimpinella anisum L. (Umbelliferae), also known as aniseed, was found to inhibit the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) by mushroom tyrosinase (EC 1.14.18.1) with an ID50 of 43 μg/mL (0.32 mM). The inhibition kinetics analyzed by a Lineweaver-Burk plot established anisaldehyde to be a noncompetitive inhibitor for this oxidation. On the ...
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The enzyme tyrosinase is known to be a multifunctional copper-containing enzyme from the oxidase superfamily, which is the key protein involved in the biosynthesis of the large biological pigment, melanin. The enzyme catalyzes two distinct reactions of melanin biosynthesis, the hydroxylation of a monophenol and the conversion of an o-diphenol to the corresponding o-quinone. Inhibitors of this p...
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In the present paper, we report the synthesis and pharmacological evaluation of a new series of azo compounds with different groups (1-naphthol, 2-naphthol, and N,N-dimethylaniline) and trifluoromethoxy and fluoro substituents in the scaffold. All synthesized compounds (5a-5f) showed the most potent mushroom tyrosinase inhibition (IC₅₀ values in the range of 4.39 ± 0.76-1.71 ± 0.49 µM), compara...
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Background and objectives: Tyrosinase is a copper containing oxidase which is crucial for controlling the production of melanin in creatures such as bacteria, fungi, plants and mammals. It is involved in the first two steps of melanin biosynthesis and leads to pigmentation and different types of cancer such as melanoma. Also, it is responsible for browning of fruits and vegetab...
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ژورنال
عنوان ژورنال: Bioscience, Biotechnology, and Biochemistry
سال: 2018
ISSN: 0916-8451,1347-6947
DOI: 10.1080/09168451.2017.1415125